Details of the dry granulator tableting method

The dry granulator belongs to a kind of granulator and has many granulator manufacturers. The tableting method of a dry granulator is to uniformly mix powders of pharmaceuticals and auxiliary materials into a large sheet or a plate. The method of smashing into particles of the desired size. This method relies on the compressive force to generate binding force between molecules. The preparation method includes a tableting method and a rolling method. The dry granulation tableting method is often used for heat-sensitive materials and drugs that are easily decomposed when exposed to water. The method is simple, labor-saving and time-saving. The process flow of Wenzhou dry granulation machine manufacturers is as follows: Drugs + accessories → smashing → sifting → mixing → briquetting → smashing → whole-grained → mixing → tableting dry granulator manufacturers' attention to the dry granulator pressing method Note 1, content must be determined after mixing. 2. The properties of drugs and excipients should be similar, so that uneven mixing can be avoided. Because the material's bulk density, particle size distribution and other physical properties are similar when the mixing uniformity is good, especially when the main drug content is small, the finished product needs to do the content uniformity, if the mixture is not good, the problem is big. 3, the incompatible lubricant is added last. Note that be sure to wait for the other dressings to mix evenly, then add the incompatible lubricant, and control the mixing time, otherwise it will affect the disintegration and dissolution. 4, when doing prescription design, we must follow the first small test and then the pilot, and finally the principle of large-scale production. 5, special attention must be paid to various abnormal conditions when pressing tablets. During the tableting process, due to equipment vibration and other reasons, the phenomenon of film slivers, poor uniformity, poor hardness, etc., may be traced and solved in a timely manner to ensure product quality.